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Integrative neurocircuits that control metabolism and food intake
JC Brüning, H Fenselau - Science, 2023 - science.org
Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …
Arcuate nucleus-dependent regulation of metabolism—pathways to obesity and diabetes mellitus
The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …
HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus
The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization …
recent progress in single-cell technologies, a unified catalog and molecular characterization …
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
Abstract Agouti-related peptide (AgRP)-expressing and proopiomelanocortin (POMC)-
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …
expressing neurons reciprocally regulate food intake. Here, we combine non-interacting …
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding
The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …
rates in the past half century, thereby posing a healthcare challenge due to the array of …
Effects of dietary fibre on metabolic health and obesity
Obesity and metabolic syndrome represent a growing epidemic worldwide. Body weight is
regulated through complex interactions between hormonal, neural and metabolic pathways …
regulated through complex interactions between hormonal, neural and metabolic pathways …
Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease
Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic
neurodegeneration in Parkinson's disease. Here we performed a high-throughput, proteome …
neurodegeneration in Parkinson's disease. Here we performed a high-throughput, proteome …
Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines
X Fu, Y Wang, F Zhao, R Cui, W **e, Q Liu… - Aging (Albany …, 2023 - pmc.ncbi.nlm.nih.gov
Depression and obesity are both common disorders currently affecting public health,
frequently occurring simultaneously within individuals, and the relationship between these …
frequently occurring simultaneously within individuals, and the relationship between these …
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
Autophagy represents a key regulator of aging and metabolism in sensing energy
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …
[HTML][HTML] Dietary fat modulation of gut microbiota and impact on regulatory pathways controlling food intake
Obesity is a multifactorial disease that continues to increase in prevalence worldwide.
Emerging evidence has shown that the development of obesity may be influenced by …
Emerging evidence has shown that the development of obesity may be influenced by …