Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Aging is an inherently complex process that is manifested within an organism at genetic,
molecular, cellular, organ, and system levels. Although the fundamental mechanisms are …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Age-related accumulation of cellular damage and death has been linked to oxidative stress.
Calorie restriction (CR) is the most robust, nongenetic intervention that increases lifespan …

As regulators of bioenergetics in the cell and the primary source of endogenous reactive
oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the …

Aging is characterized by decrements in maximum function and accumulation of
mitochondrial DNA mutations, which are best observed in organs such as the brain that …

Reactive oxygen species (ROS) are considered an important factor in ischemia/reperfusion
injury to cardiac myocytes. Mitochondrial respiration is an important source of ROS …

Calorie restriction (CR) increases longevity and retards the development of many chronic
diseases, but the underlying metabolic signals are poorly understood. Increased fatty acid …