Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Physical properties of blood and their relationship to clinical conditions

T Alexy, J Detterich, P Connes, K Toth, E Nader… - Frontiers in …, 2022 - frontiersin.org
It has been long known that blood health heavily influences optimal physiological function.
Abnormalities affecting the physical properties of blood have been implicated in the …

Artificial cells for in vivo biomedical applications through red blood cell biomimicry

J Waeterschoot, W Gosselé, Š Lemež… - Nature …, 2024 - nature.com
Recent research in artificial cell production holds promise for the development of delivery
agents with therapeutic effects akin to real cells. To succeed in these applications, these …

Backmap** triangulated surfaces to coarse-grained membrane models

W Pezeshkian, M König, TA Wassenaar… - Nature …, 2020 - nature.com
Many biological processes involve large-scale changes in membrane shape. Computer
simulations of these processes are challenging since they occur across a wide range of …

Metabolic influences modulating erythrocyte deformability and eryptosis

JF Brun, E Varlet-Marie, J Myzia… - Metabolites, 2021 - mdpi.com
Many factors in the surrounding environment have been reported to influence erythrocyte
deformability. It is likely that some influences represent reversible changes in erythrocyte …

Advances in microfluidics for single red blood cell analysis

GV Grigorev, AV Lebedev, X Wang, X Qian… - Biosensors, 2023 - mdpi.com
The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted
great interests in recent years to filter, trap, analyze, and release single erythrocytes for …

Venous thromboembolism: review of Clinical challenges, Biology, Assessment, Treatment, and modeling

C Watson, H Saaid, V Vedula, JC Cardenas… - Annals of Biomedical …, 2024 - Springer
Venous thromboembolism (VTE) is a massive clinical challenge, annually affecting millions
of patients globally. VTE is a particularly consequential pathology, as incidence is correlated …

[HTML][HTML] Red blood cells tracking and cell-free layer formation in a microchannel with hyperbolic contraction: A CFD model validation

M Gracka, R Lima, JM Miranda, S Student… - Computer Methods and …, 2022 - Elsevier
Abstract Background and Objective In recent years, progress in microfabrication
technologies has attracted the attention of researchers across disciplines. Microfluidic …

Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries

C Arakawa, C Gunnarsson, C Howard, M Bernabeu… - Science …, 2020 - science.org
Microcirculatory obstruction is a hallmark of severe malaria, but mechanisms of parasite
sequestration are only partially understood. Here, we developed a robust three-dimensional …

Red blood cell shape transitions and dynamics in time-dependent capillary flows

SM Recktenwald, K Graessel, FM Maurer, T John… - Biophysical …, 2022 - cell.com
The dynamics of single red blood cells (RBCs) determine microvascular blood flow by
adapting their shape to the flow conditions in the narrow vessels. In this study, we explore …