Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the
regulation of gene expression. They are involved in the fine-tuning of fundamental biological …

Obesity represents a risk factor for development of insulin resistance and type 2 diabetes. In
addition, it has been associated with increased adipocyte formation in the bone marrow …

Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

Many older persons lose their mobility and independence due to multiple diseases
occurring simultaneously. Geroscience is aimed at develo** innovative approaches to …

Obesity is a worldwide epidemic responsible for 5% of global mortality. The risks of
develo** other key metabolic disorders like diabetes, hypertension and cardiovascular …

The discovery of microRNAs (miRNAs) 20 years ago has advocated a new era of “small
molecular genetics.” About 2000 miRNAs are present that regulate one third of the genome …

Bone marrow (BM) microenvironment represents an important compartment of bone that
regulates bone homeostasis and the balance between bone formation and bone resorption …

Epigenetic abnormalities are part of the pathogenetic alterations involved in the
development of rheumatic disorders. In this context, the main musculoskeletal cell lineages …