Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking

J Conniot, JM Silva, JG Fernandes, LC Silva… - Frontiers in …, 2014 - frontiersin.org
Cancer is one of the most common diseases afflicting people globally. New therapeutic
approaches are needed due to the complexity of cancer as a disease. Many current …

[HTML][HTML] Mimicking the native bone regenerative microenvironment for in situ repair of large physiological and pathological bone defects

P Wang, X Wang - Engineered Regeneration, 2022 - Elsevier
Bone is a complex biological tissue with a complicated hierarchical nanocomposite
structure. The native microenvironment of the bone tissue may be significantly disrupted by …

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo

J Lv, H Lan, A Qin, T Sun, D Shao, F Gao… - Light: Science & …, 2024 - nature.com
Advancements in precision medicine necessitate understanding drug clearance pathways,
especially in organs like the liver and kidneys. Traditional techniques such as PET/CT pose …

Protein based biomaterials for therapeutic and diagnostic applications

S Chu, AL Wang, A Bhattacharya… - Progress in Biomedical …, 2021 - iopscience.iop.org
Proteins are some of the most versatile and studied macromolecules with extensive
biomedical applications. The natural and biological origin of proteins offer such materials …

Guidelines for the experimental design of pharmacokinetic studies with nanomaterials in preclinical animal models

MS Valic, M Halim, P Schimmer, G Zheng - Journal of Controlled Release, 2020 - Elsevier
A shared feature in the value proposition of every nanomaterial-based drug delivery systems
is the desirable improvement in the disposition (or ADME) and pharmacokinetic profiles of …

[HTML][HTML] Longitudinal imaging of the ageing mouse

E Dall'Ara, M Boudiffa, C Taylor, D Schug… - Mechanisms of ageing …, 2016 - Elsevier
Several non-invasive imaging techniques are used to investigate the effect of pathologies
and treatments over time in mouse models. Each preclinical in vivo technique provides …

Classification of the Multiple Stages of Parkinson's Disease by a Deep Convolution Neural Network Based on 99mTc-TRODAT-1 SPECT Images

SY Hsu, LR Yeh, TB Chen, WC Du, YH Huang… - Molecules, 2020 - mdpi.com
Single photon emission computed tomography (SPECT) has been employed to detect
Parkinson's disease (PD). However, analysis of the SPECT PD images was mostly based on …

Biomarkers in preclinical cancer imaging

MR Bernsen, K Kooiman, M Segbers… - European journal of …, 2015 - Springer
In view of the trend towards personalized treatment strategies for (cancer) patients, there is
an increasing need to noninvasively determine individual patient characteristics. Such …

Characterization of the detection module of the INSERT SPECT/MRI clinical system

M Occhipinti, M Carminati, P Busca… - … on Radiation and …, 2018 - ieeexplore.ieee.org
Within the vast panorama of multimodal systems for clinical diagnosis, PET/MRI has been
receiving significant attention. In parallel, new technological solutions have been paving the …

In vivo imaging with confirmation by histopathology for increased rigor and reproducibility in translational research: a review of examples, options, and resources

K Gabrielson, R Maronpot, S Monette… - ILAR …, 2018 - academic.oup.com
Preclinical noninvasive imaging can be an indispensable tool for studying animal models of
disease. In vivo imaging to assess anatomical, functional, and molecular features requires …