Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …

Lipoproteins and Atherosclerosis Christopher K. Glass*†‡ and Joseph L. Witztum*
Specialized Center of Research on Molecular Serum cholesterol is carried by several …

Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

Growing evidence indicates that chronic and acute overproduction of reactive oxygen
species (ROS) under pathophysiologic conditions is integral in the development of …

HDL levels are inversely related to the risk of develo** atherosclerosis. In serum,
paraoxonase (PON) is associated with HDL, and was shown to inhibit LDL oxidation …

Chance and serendipity play major roles in the history of science. Too often, though, their
contributions do not show up in formal publications. We all tend to shape history according …

Background: Dietary supplementation with nutrients rich in antioxidants is associated with
inhibition of atherogenic modifications to LDL, macrophage foam cell formation, and …

Obstructive sleep apnoea syndrome (OSA) is associated with increased cardiovascular
morbidity and mortality. However, the underlying mechanisms are not entirely understood …

Epidemiologic studies have demonstrated an association between increased intake of
antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality …