A large and complex gene on the X chromosome encodes dystrophin. Many mutations have
been described in this gene, most of which affect the expression of the muscle isoform, the …

Dystrophinopathies result from mutations of the DMD gene that primarily affect skeletal
muscle but also affect heart, brain, and smooth muscle. Advances in the genetic analysis of …

OBJECTIVES This study was performed to evaluate the characteristics, mode of inheritance
and etiology of familial dilated cardiomyopathy (FDC). BACKGROUND A genetic form of …

Cardiomyopathies are diseases of heart muscle that may result from a diverse array of
conditions that damage the heart and other organs and impair myocardial function, including …

Genetic approaches have succeeded in defining the molecular basis of an increasing array
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes …

Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular
dilatation and impaired systolic function. Patients with DCM suffer from heart failure …

Mutations in the dystrophin gene give rise to Duchenne and Becker muscular dystrophies
(DMD and BMD), in which both skeletal and cardiac muscles are affected, but also to X …

Cardiomyopathies are serious heart muscle disorders in children and adults, which result in
morbidity and premature death. These disorders include hypertrophic cardiomyopathy …

Background Several cases of Becker's muscular dystrophy (BMD) have been reported,
which showed mild or subclinical skeletal muscle involvement with an overt dilated …

The BIO14. 6 hamster is a widely used model for autosomal recessive cardiomyopathy.
These animals die prematurely from progressive myocardial necrosis and heart failure. The …