The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine
with anti‐depressant effects, interacting with other drugs, altering their bioavailability and …

As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is
a ligand-activated transcription factor that plays a crucial role in the metabolism of …

Drug-resistant epilepsy (DRE) is present in 20-30% of all patients who develop epilepsy.
Growing evidences demonstrated that glutamate released during seizures to increase the …

Atherosclerosis is a major global health concern. The central modifiable risk factors and
causative agents of the disease are high total and low-density lipoprotein (LDL) cholesterol …

ABC transporters have a significant role in drug disposition and response and various
studies have implicated their involvement in epilepsy pharmacoresistance. Since genetic …

The incidence of nonalcoholic fatty liver disease (NAFLD) has been rising worldwide in
parallel with diabetes and metabolic syndrome. NAFLD refers to a spectrum of liver …

ABSTRACT Cytochrome P450 1A1 (CYP1A1) actively catalyzes estrogen hydroxylation
reactions and maintains the levels of neuroactive steroid estradiol. The widely prescribed …

Cholestatic liver injury (CLI) is caused by toxic bile acids (BAs) accumulation in the liver and
can lead to inflammation and liver fibrosis. The mechanisms underlying CLI development …

Abstract Superoxide dismutase 2 (SOD2) is a key enzyme for scavenging reactive oxygen
species produced by mitochondria, which plays an important role in maintaining cellular …

Abstract Pregnane & Xenobiotic Receptor (PXR) is one of the 48 members of the ligand-
modulated transcription factors belonging to nuclear receptor superfamily. Though PXR is …