Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Plants produce a myriad of structurally and functionally diverse metabolites that play many
different roles in plant growth and development and in plant response to continually …

Neutropenia represents an important problem in patients with genetic deficiency in either the
glucose-6-phosphate transporter of the endoplasmic reticulum (G6PT/SLC37A4) or G6PC3 …

Highlights•Cell-free systems enable biochemical reactions in the absence of cell viability
constraints.•Cell-free metabolic engineering presents opportunities for biomanufacturing …

Specific point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in a
variety of cancers, including acute myeloid leukemia (AML), low-grade gliomas, and …

Hundreds of metabolic enzymes work together smoothly in a cell. These enzymes are highly
specific. Nevertheless, under physiological conditions, many perform side-reactions at low …

The substrate specificity of enzymes is bound to be imperfect, because of unavoidable
physicochemical limits. In extant metabolic enzymes, furthermore, such limits are seldom …

Metabolic enzymes are very specific. However, most of them show weak side activities
toward compounds that are structurally related to their physiological substrates, thereby …

The post-genomic era has provided researchers with a deluge of protein sequences.
However, a significant fraction of the proteins encoded by sequenced genomes remains …

Cellular metabolism assembles in a structurally highly conserved, but functionally dynamic
system, known as the metabolic network. This network involves highly active, enzyme …