Biomarkers of checkpoint inhibitor induced immune-related adverse events—a comprehensive review

JW Hommes, RJ Verheijden, KPM Suijkerbuijk… - Frontiers in …, 2021 - frontiersin.org
Immune checkpoint inhibitors (ICIs) have substantially improved the prognosis of patients
with different types of cancer. Through blockade of cytotoxic T-lymphocyte antigen 4 (CTLA …

Classical examples of the concept of the ASIA syndrome

V Borba, A Malkova, N Basantsova, G Halpert… - Biomolecules, 2020 - mdpi.com
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in
2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases …

Immune checkpoint inhibitor-associated pneumonitis in non-small cell lung cancer: current understanding in characteristics, diagnosis, and management

Q Zhang, L Tang, Y Zhou, W He, W Li - Frontiers in immunology, 2021 - frontiersin.org
Immunotherapy that includes programmed cell death-1 (PD-1), programmed cell death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors has …

Predictive biomarkers for checkpoint inhibitor immune-related adverse events

I Les, M Martinez, I Perez-Francisco, M Cabero… - Cancers, 2023 - mdpi.com
Simple Summary Immune-checkpoint inhibitors (ICIs) are increasingly used in the treatment
of cancer, but they cause immune-related adverse events (irAEs) in around 40% of patients …

Checkpoint inhibitor pneumonitis induced by anti-PD-1/PD-L1 therapy in non-small-cell lung cancer: occurrence and mechanism

J Yin, Y Wu, X Yang, L Gan, J Xue - Frontiers in Immunology, 2022 - frontiersin.org
Immune checkpointty inhibitors (ICIs), particularly those targeting programmed death 1 (PD-
1) and anti-programmed death ligand 1 (PD-L1), enhance the antitumor effect by restoring …

Multi-omics analysis uncovers tumor ecosystem dynamics during neoadjuvant toripalimab plus nab-paclitaxel and S-1 for esophageal squamous cell carcinoma: a …

G Zhang, J Yuan, C Pan, Q Xu, X Cui, J Zhang, M Liu… - …, 2023 - thelancet.com
Background Immune checkpoint inhibitors combined with chemotherapy as a neoadjuvant
therapy have been applied to the treatment of esophageal squamous cell carcinoma …

[HTML][HTML] Biomarkers, clinical features, and rechallenge for immune checkpoint inhibitor renal immune-related adverse events

B Isik, MP Alexander, S Manohar, L Vaughan… - Kidney International …, 2021 - Elsevier
Introduction Immune checkpoint inhibitors (ICIs) are effective in treating several cancers;
however, acute kidney injury (AKI) can occur as part as an immune-related adverse event …

[HTML][HTML] The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients

X Zhai, J Zhang, Y Tian, J Li, W **g… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are new and promising therapeutic agents for non-small
cell lung cancer (NSCLC). However, along with demonstrating remarkable efficacy, ICIs can …

[HTML][HTML] Gut microbiota changes and its potential relations with thyroid carcinoma

X Yu, W Jiang, RO Kosik, Y Song, Q Luo, T Qiao… - Journal of advanced …, 2022 - Elsevier
Introduction Emerging evidence suggests that the essence of life is the ecological balance of
the neural, endocrine, metabolic, microbial, and immune systems. Gut microbiota have been …

[HTML][HTML] Lower baseline autoantibody levels are associated with immune-related adverse events from immune checkpoint inhibition

N Ghosh, M Postow, C Zhu, D Jannat-Khah… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Methods This study used data from an oncologic clinical trial of adaptive dosing combination
ICI therapy in patients with advanced melanoma. Plasma was collected at baseline and 6 …