In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Recently, cuproptosis has been demonstrated to be a new non-apototic cell death mode that
is characterized by copper dependence and the regulation of mitochondrial respiration …

Abstract VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in
angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its …

Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …

Cell death constitutes a critical component of the pathophysiology of cardiovascular
diseases. A growing array of non-apoptotic forms of regulated cell death (RCD)—such as …

Heavy metal exposure can lead to death and disability. A variety of sources including soil,
wastewater, mining activities, industrial waste, sewage wastes, pesticides used in …

Myocardial infarction (MI) is a leading cause of death worldwide. Few drugs hold the ability
to depress cardiac electrical and structural remodeling simultaneously after MI, which is …

Introduction Coronary artery disease possess inflammatory background related to enzymatic
processes with trace elements involvements as co-factors. The aim of the study was to …

Cuproptosis is a novel form of regulated cell death, which plays an important role in the
physiological and pathological processes of the human body. Despite the increasing …