Second-generation antiandrogens: from discovery to standard of care in castration resistant prostate cancer
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States.
The prostate is a hormone-dependent gland in which androgen hormones testosterone and …
The prostate is a hormone-dependent gland in which androgen hormones testosterone and …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
[HTML][HTML] Drugging the 'undruggable'. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods
Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently
regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein …
regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein …
ETS transcription factors as emerging drug targets in cancer
The ETS family of proteins consists of 28 transcription factors, many of which have been
implicated in development and progression of a variety of cancers. While one family …
implicated in development and progression of a variety of cancers. While one family …
Molecular mechanisms and genetic alterations in prostate cancer: From diagnosis to targeted therapy
F Fontana, M Anselmi, P Limonta - Cancer Letters, 2022 - Elsevier
Prostate cancer remains one of the most lethal malignancies among men worldwide.
Although the primary tumor can be successfully managed by surgery and radiotherapy …
Although the primary tumor can be successfully managed by surgery and radiotherapy …
ETS factors in prostate cancer
The ETS family of proteins consists of 28 transcription factors, many of which play critical
roles in both normal tissue development and homeostasis and have been implicated in …
roles in both normal tissue development and homeostasis and have been implicated in …
Past, current, and future strategies to target ERG fusion-positive prostate cancer
Simple Summary In addition to its role in development and in the vascular and
hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50 …
hematopoietic systems, ERG plays a central role in prostate cancer. Approximately 40–50 …
Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG
Genome-wide association studies have identified 270 loci conferring risk for prostate cancer
(PCa), yet the underlying biology and clinical impact remain to be investigated. Here we …
(PCa), yet the underlying biology and clinical impact remain to be investigated. Here we …
Androgen-driven fusion genes and chimeric transcripts in prostate cancer
M Scaravilli, S Koivukoski, L Latonen - Frontiers in Cell and …, 2021 - frontiersin.org
Androgens are steroid hormones governing the male reproductive development and
function. As such, androgens and the key mediator of their effects, androgen receptor (AR) …
function. As such, androgens and the key mediator of their effects, androgen receptor (AR) …
Oncogenic ETS factors in prostate cancer
Prostate cancer is unique among carcinomas in that a fusion gene created by a
chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG …
chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG …