Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

[HTML][HTML] Antimicrobial activity of 1, 3, 4-oxadiazole derivatives

T Glomb, P Świątek - International journal of molecular sciences, 2021 - mdpi.com
The worldwide development of antimicrobial resistance forces scientists to search for new
compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …

[HTML][HTML] Synthesis, in vitro thymidine phosphorylase inhibitory activity and molecular docking study of novel pyridine-derived bis-oxadiazole bearing bis-schiff base …

R Hussain, W Rehman, F Rahim, S Khan… - Arabian Journal of …, 2023 - Elsevier
The current study has afforded twelve analogs (4a-l) of pyridine-derived bis-oxadiazole
containing bis-schiff base and subsequently evaluated for their potential to inhibit thymidine …

[HTML][HTML] An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

1, 2, 4-and 1, 3, 4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents

P Pitasse-Santos, V Sueth-Santiago… - Journal of the Brazilian …, 2018 - SciELO Brasil
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design
and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the …

Visible light‐mediated photocatalyzed synthesis of oxazole via intermolecular C N and C O bond formation

MZ Beg, S Tivari, A Kashyap, PK Singh… - Journal of …, 2024 - Wiley Online Library
An efficient visible light‐mediated, eosin Y‐catalyzed synthesis of oxazole has been
developed from benzil with primary amines, that providing a straightforward, green, and …

[HTML][HTML] Recent advances in the synthesis of oxazole-based molecules via van leusen oxazole synthesis

X Zheng, W Liu, D Zhang - Molecules, 2020 - mdpi.com
Oxazole compounds, including one nitrogen atom and one oxygen atom in a five-membered
heterocyclic ring, are present in various biological activities. Due to binding with a …

Synthesis of novel 5-(2, 5-bis (2, 2, 2-trifluoroethoxy) phenyl)-1, 3, 4-oxadiazole-2-thiol derivatives as potential glucosidase inhibitors

RS Gani, AK Kudva, K Timanagouda, SBH Mujawar… - Bioorganic …, 2021 - Elsevier
Background A hybrid molecule of different biologically active substances can improve affinity
and efficiency compared to a standard drug. Hence based on this fact, we predict that a …

[HTML][HTML] In-silico studies of some oxadiazoles derivatives as anti-diabetic compounds

MT Ibrahim, A Uzairu, GA Shallangwa… - Journal of King Saud …, 2020 - Elsevier
An in-silico study was performed to investigate the anti-diabetic activities of 27 Oxadiazoles
derivatives. The anti-diabetic compounds were optimized using Density Functional Theory …

[HTML][HTML] Aryl-oxadiazole Schiff bases: Synthesis, α-glucosidase in vitro inhibitory activity and their in silico studies

H Ullah, F Rahim, M Taha, R Hussain… - Arabian Journal of …, 2020 - Elsevier
Abstract α-Glucosidase enzyme is a therapeutic target for diabetes mellitus and its inhibitors
play a vital role in the treatment of this disease. A new series of aryl-oxadiazole Schiff bases …