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Protein acylation: mechanisms, biological functions and therapeutic targets
S Shang, J Liu, F Hua - Signal transduction and targeted therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …
Acute promyelocytic leukemia: a paradigm for oncoprotein-targeted cure
Recent clinical trials have demonstrated that the immense majority of acute promyelocytic
leukemia (APL) patients can be definitively cured by the combination of two targeted …
leukemia (APL) patients can be definitively cured by the combination of two targeted …
TRIB3 reduces CD8+ T cell infiltration and induces immune evasion by repressing the STAT1-CXCL10 axis in colorectal cancer
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
Cellular senescence: the sought or the unwanted?
Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …
The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer
Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …
time, the burden of cancer continues to increase. The underlying molecular pathways …
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis.
However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed …
However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed …
TRIB3 interacts with β-catenin and TCF4 to increase stem cell features of colorectal cancer stem cells and tumorigenesis
F Hua, S Shang, Y Yang, H Zhang, T Xu, J Yu, D Zhou… - Gastroenterology, 2019 - Elsevier
Background & Aims Activation of Wnt signaling to β-catenin contributes to the development
of colorectal cancer (CRC). Expression of tribbles pseudo-kinase 3 (TRIB3) is increased in …
of colorectal cancer (CRC). Expression of tribbles pseudo-kinase 3 (TRIB3) is increased in …
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related
to tumor progression and therapy resistance across cancer types, including non-small cell …
to tumor progression and therapy resistance across cancer types, including non-small cell …
Recent advances in IAP-based PROTACs (SNIPERs) as potential therapeutic agents
C Wang, Y Zhang, L Shi, S Yang, J Chang… - Journal of Enzyme …, 2022 - Taylor & Francis
Proteolytic targeting chimaeras (PROTACs) have been developed as an effective
technology for targeted protein degradation. PROTACs are heterobifunctional molecules …
technology for targeted protein degradation. PROTACs are heterobifunctional molecules …