3D cell culture systems: tumor application, advantages, and disadvantages
O Habanjar, M Diab-Assaf, F Caldefie-Chezet… - International journal of …, 2021 - mdpi.com
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …
been used in cancer research. However, this system cannot be fully translated into clinical …
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Enhanced substrate stress relaxation promotes filopodia-mediated cell migration
Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the
leading edge, mature focal adhesions and spread morphologies. These observations result …
leading edge, mature focal adhesions and spread morphologies. These observations result …
Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance
JC Fontoura, C Viezzer, FG Dos Santos… - Materials Science and …, 2020 - Elsevier
In vitro drug screening is widely used in the development of new drugs, because they
constitute a cost-effective approach to select compounds with more potential for therapy …
constitute a cost-effective approach to select compounds with more potential for therapy …
Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
Studies of cancer cell migration have found two modes: one that is protease-independent,
requiring micron-sized pores or channels for cells to squeeze through, and one that is …
requiring micron-sized pores or channels for cells to squeeze through, and one that is …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
[HTML][HTML] Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells
The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer
cells to adapt their migration mode to their environment. While the molecular pathways …
cells to adapt their migration mode to their environment. While the molecular pathways …
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
[HTML][HTML] Cancer invasion and the microenvironment: plasticity and reciprocity
Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …
molecular determinants adapt and react throughout the progression of the disease. Cancer …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …