Applied hydroformylation

R Franke, D Selent, A Börner - Chemical reviews, 2012 - ACS Publications
Hydroformylation is the addition of synthesis gas (“syngas”), a mixture of CO and H2, to
olefins in the presence of a catalyst under the formation of aldehydes. Hydrogen (“hydro”) …

Computational ligand descriptors for catalyst design

DJ Durand, N Fey - Chemical reviews, 2019 - ACS Publications
Ligands, especially phosphines and carbenes, can play a key role in modifying and
controlling homogeneous organometallic catalysts, and they often provide a convenient …

Data-driven multi-objective optimization tactics for catalytic asymmetric reactions using bisphosphine ligands

JJ Dotson, L van Dijk, JC Timmerman… - Journal of the …, 2022 - ACS Publications
Optimization of the catalyst structure to simultaneously improve multiple reaction objectives
(eg, yield, enantioselectivity, and regioselectivity) remains a formidable challenge. Herein …

[BOOK][B] Rhodium catalyzed hydroformylation

PWNM Van Leeuwen, C Claver - 2002 - books.google.com
In the last decade there have been numerous advances in the area of rhodium-catalyzed
hydroformylation, such as highly selective catalysts of industrial importance, new insights …

Building a toolbox for the analysis and prediction of ligand and catalyst effects in organometallic catalysis

DJ Durand, N Fey - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Computers have become closely involved with most aspects of modern life, and
these developments are tracked in the chemical sciences. Recent years have seen the …

Quantum-mechanical transition-state model combined with machine learning provides catalyst design features for selective Cr olefin oligomerization

SM Maley, DH Kwon, N Rollins, JC Stanley… - Chemical …, 2020 - pubs.rsc.org
The use of data science tools to provide the emergence of non-trivial chemical features for
catalyst design is an important goal in catalysis science. Additionally, there is currently no …

Hybrid diphosphorus ligands in rhodium catalysed asymmetric hydroformylation

SH Chikkali, JI van der Vlugt, JNH Reek - Coordination chemistry reviews, 2014 - Elsevier
This review aims to illustrate recent advances in the application of hybrid diphosphorus
ligands for the Rh catalysed hydroformylation of alkenes, discussing the most prevalent …

Ligand-Based Principal Component Analysis Followed by Ridge Regression: Application to an Asymmetric Negishi Reaction

HR Kelly, S Sreekumar, V Manee, AE Cuomo… - ACS …, 2024 - ACS Publications
In this study, we introduce an approach for predicting the enantioselectivity of P-chiral
monophosphorus ligands from ligand-based descriptors that can be applied to catalytic …

Understanding Rh‐catalysed Hydroformylation with Phosphite Ligands through Catalyst Speciation Analysis by Operando FlowNMR Spectroscopy

A Bara‐Estaún, CL Lyall, JP Lowe, PG Pringle… - …, 2023 - Wiley Online Library
Phosphites are industrially important ligands for the Rh‐catalysed hydroformylation of
olefins because they produce more active catalysts than phosphines, which is mainly due to …

Expansion of the ligand knowledge base for chelating P, P-donor ligands (LKB-PP)

J Jover, N Fey, JN Harvey, GC Lloyd-Jones… - …, 2012 - ACS Publications
We have expanded the ligand knowledge base for bidentate P, P-and P, N-donor ligands
(LKB-PP, Organometallics 2008, 27, 1372–1383) by 208 ligands and introduced an …