Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

Melatonin is an old and ubiquitous molecule in nature showing multiple mechanisms of
action and functions in practically every living organism. In mammals, pineal melatonin …

Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Pineal melatonin secretion declines with aging, whereas visceral fat, plasma insulin, and
plasma leptin tend to increase. We have previously demonstrated that daily melatonin …

Melatonin is a neurohormone synthesized from dietary tryptophan in various organs,
including the pineal gland and the retina. In the pineal gland, melatonin is produced at night …

Melatonin is involved in the regulation of seasonal obesity in various species, including
some rodents. This involvement has been demonstrated in nonphotoperiodic rodents like …

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an
important modulator of a number of physiological functions. In addition to its rather well …

Adipogenesis and osteogenesis, a reciprocal relationship in bone marrow, are complex
processes including proliferation of precursor cells, commitment to the specific lineage, and …

The environment in which an animal lives affects the physiology and psychology of that
animal. The greater the distance from the equator the more profound this influence …