Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …

Physical activity decreases the risk of a network of diseases, and exercise may be
prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia …

The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …

The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

In the healthy state, the fat stored in our body isn't just inert. Rather, it is dynamically
mobilized to maintain an adequate concentration of fatty acids (FAs) in our bloodstream. Our …

Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with
obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary …

In this review, we provide a brief synopsis of the connections between adipose tissue and
metabolic health and highlight some recent developments in understanding and exploiting …

Abstract Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …