As the gap between donors and patients in need of an organ transplant continues to widen,
research in regenerative medicine seeks to provide alternative strategies for treatment. One …

Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

The application of nanotechnology in medicine, referred to as nanomedicine, is offering
numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of …

A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial
and mechanical cues to which cells respond. In addition to soluble chemical factors …

Cell–material interactions constitute a key fundamental topic in biomaterials study. Various
cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

The interaction of mammalian cells with nanoscale topography has proven to be an
important signaling modality in controlling cell function. Naturally occurring nanotopographic …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …