Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable
prognosis and a satisfactory response to immunotherapy; however, the vast majority of …

Lung cancer causes the highest mortality compared to other cancers in the world according
to the latest WHO reports. Non-small cell lung cancer (NSCLC) contributes about 85% of …

As an important post-translational modification, ubiquitination mediates∼ 80% of protein
degradation in eukaryotes. The degree of protein ubiquitination is tightly determined by the …

Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Although chemotherapy is a first option in treatment of cancer patients, drug resistance has
led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching …

Due to cell mutation and self-adaptation, the application of clinical drugs with early
epidermal growth factor receptor (EGFR)-targeted inhibitors is severely limited. To overcome …

The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …

Palbociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer by suppressing
cell proliferation. However, monotherapy with palbociclib was discouraging in prostate …