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Architecture, function, regulation, and evolution of α-glucans metabolic enzymes in prokaryotes
Bacteria have acquired sophisticated mechanisms for assembling and disassembling
polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α …
polysaccharides of different chemistry. α-d-Glucose homopolysaccharides, so-called α …
Trehalose and bacterial virulence
Trehalose is a disaccharide of two D-glucose molecules linked by a glycosidic linkage,
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …
which plays both structural and functional roles in bacteria. Trehalose can be synthesized …
Genomewide assessment of Mycobacterium tuberculosis conditionally essential metabolic pathways
ABSTRACT A better understanding of essential cellular functions in pathogenic bacteria is
important for the development of more effective antimicrobial agents. We performed a …
important for the development of more effective antimicrobial agents. We performed a …
Trehalose transport occurs via TreB in Listeria monocytogenes and it influences biofilm development and acid resistance
Listeria monocytogenes is a pathogenic bacterium that can inhabit a diverse range of
environmental niches. This is largely attributed to the high proportion of carbohydrate …
environmental niches. This is largely attributed to the high proportion of carbohydrate …
Sugar-phosphate toxicities
Accumulation of phosphorylated intermediates during cellular metabolism can have wide-
ranging toxic effects on many organisms, including humans and the pathogens that infect …
ranging toxic effects on many organisms, including humans and the pathogens that infect …
Transposon sequencing reveals metabolic pathways essential for Mycobacterium tuberculosis infection
AM Block, PC Wiegert, SB Namugenyi… - PLoS …, 2024 - journals.plos.org
New drugs are needed to shorten and simplify treatment of tuberculosis caused by
Mycobacterium tuberculosis. Metabolic pathways that M. tuberculosis requires for growth or …
Mycobacterium tuberculosis. Metabolic pathways that M. tuberculosis requires for growth or …
Trehalose recycling promotes energy-efficient biosynthesis of the mycobacterial cell envelope
The mycomembrane layer of the mycobacterial cell envelope is a barrier to environmental,
immune, and antibiotic insults. There is considerable evidence of mycomembrane plasticity …
immune, and antibiotic insults. There is considerable evidence of mycomembrane plasticity …
Trehalose phosphate synthase complex-mediated regulation of trehalose 6-phosphate homeostasis is critical for development and pathogenesis in Magnaporthe …
Trehalose biosynthesis pathway is a potential target for antifungal drug development, and
trehalose 6-phosphate (T6P) accumulation is widely known to have toxic effects on cells …
trehalose 6-phosphate (T6P) accumulation is widely known to have toxic effects on cells …
A putative terpene cyclase gene (CcPtc1) is required for fungal development and virulence in Cytospora chrysosperma
Y Yang, L Yu, X Qiu, D **ong, C Tian - Frontiers in Microbiology, 2023 - frontiersin.org
Cytospora chrysosperma is a destructive plant pathogenic fungus, which causes canker
disease on numerous woody plants. However, knowledge concerning the interaction …
disease on numerous woody plants. However, knowledge concerning the interaction …
Trehalose‐6‐phosphate‐mediated phenotypic change in Acinetobacter baumannii
JJ Hubloher, S Zeidler, P Lamosa… - Environmental …, 2020 - Wiley Online Library
The stress protectant trehalose is synthesized in Acinetobacter baumannii from UPD‐
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that …
glucose and glucose‐6‐phosphase via the OtsA/OtsB pathway. Previous studies proved that …