Proper patterning of the nervous system requires that develo** axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly
expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as …

It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in
the synovium; however, recent studies reveal that pain scores in patients do not correlate …

Neuronal growth cones navigate over long distances along specific pathways to find their
correct targets. The mechanisms and molecules that direct this pathfinding are the topics of …

Urate, a naturally occurring product of purine metabolism, is a scavenger of biological
oxidants implicated in numerous disease processes,,, as demonstrated by its capacity of …

The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and
comprehensive presentation of the discipline of neuroscience, from molecules to cognition …

The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

Axons are guided along specific pathways by attractive and repulsive cues in the
extracellular environment. Genetic and biochemical studies have led to the identification of …

The guidance of axons to their targets in the develo** nervous system is believed to
involve dlffuslble chemotroplc factors secreted by target cells. Floor plate cells at the ventral …

Extending axons in the develo** nervous system are guided in part by repulsive cues.
Genetic analysis in Drosophila, reported in a companion to this paper, identifies the Slit …