A longstanding goal in neuroscience has been to image membrane voltage across a
population of individual neurons in an awake, behaving mammal. Here we describe a …

The model research animal Caenorhabditis elegans has unique properties making it
particularly advantageous for studies of the nervous system. The nervous system is …

Optical imaging is a useful tool to acquire neural activities because of its high spatial
resolution, and various voltage indicators were developed to image membrane potential of …

Protein engineering through directed evolutison is facilitated by the screening and
characterization of protein libraries. Efficient and effective methods for multiple site …

Precise measurement of action potentials (APs) is needed to observe electrical activity and
cellular communication within cardiac tissue. Voltage-sensitive dyes (VSDs) are traditionally …

Protein engineering through directed evolution facilitates the screening and characterization
of protein libraries. Efficient and effective methods for multiple site-saturation mutagenesis …

The stability of neural dynamics arises through a tight coupling of excitatory (E) and
inhibitory (I) signals. Genetically encoded voltage indicators (GEVIs) can report both spikes …

Each year, over one million people in the United States have a myocardial infarction (MI).
After an infarct, the affected region undergoes massive cell death and a pathological fibrotic …

Current developments in the manufacturing of silicon probes allow recording of spikes from
large populations of neurons from several brain structures in freely moving animals. It is still …

The basal ganglia circuit has long been recognized as an important regulator for movement
in the brain, with dysfunction of this circuit resulting in motor disorders such as Parkinson's …