The past decade has seen the convergence of a series of new insights that arose from
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …

In the last few decades, mounting evidence has highlighted that microglia have crucial roles
in both health and disease. This has led to a growing interest in studying human microglia in …

Background Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative
disease characterised by the loss of upper and lower motor neurons. Increasing evidence …

Multiple lines of evidence implicate dysregulated microglia-mediated synaptic pruning in the
pathophysiology of schizophrenia. In vitro human cellular studies represent a promising …

Microglia have been implicated in Alzheimer's disease (AD) pathogenesis through the
identification of risk factor genes that are specifically or predominantly expressed in this cell …

Targeting the unique glioma immune microenvironment is a promising approach in
develo** breakthrough immunotherapy treatments. However, recent advances in …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the
accumulation of amyloid plaques, phosphorylated tau tangles and microglia toxicity …

Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2
polarized microglia in ischemic stroke, suggesting that microglia may be involved in the …

Neurodegenerative diseases are deteriorating conditions of the nervous system that are
rapidly increasing in the ageing population. Increasing evidence suggests that …

Neuroinflammation, in which activated microglia are involved, appears to contribute to the
development of Parkinson's disease (PD). However, the role of microglial activation and the …