Zika virus (ZIKV) infection during pregnancy may be linked to fetal neurological
complications that include brain damage and microcephaly. How the viral infection relates to …

Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

Neurons display a highly polarized microtubule network that mediates trafficking throughout
the extensive cytoplasm and is crucial for neuronal differentiation and function. In newborn …

Microtubule nucleation is templated by the γ-tubulin ring complex (γ-TuRC), but its structure
deviates from the geometry of α-/β-tubulin in the microtubule, explaining the complex's poor …

The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …

The ubiquitin–proteasome system degrades ubiquitin‐modified proteins to maintain protein
homeostasis and to control signalling. Whole‐genome sequencing of patients with severe …

Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts
nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the …

Retinitis pigmentosa is a group of genetically transmitted disorders affecting 1 in 3000–8000
individual people worldwide ultimately affecting the quality of life. Retinitis pigmentosa is …

Centriole biogenesis and maintenance are crucial for cells to generate cilia and assemble
centrosomes that function as microtubule organizing centers (MTOCs). Centriole biogenesis …

Primary microcephalies (PMs) are defects in brain growth that are detectable at or before
birth and are responsible for neurodevelopmental disorders. Most are caused by biallelic or …