Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …

Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …

DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or
chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede DNA-based …

Covalent DNA–protein cross-links (DPCs) are toxic DNA lesions that block replication and
require repair by multiple pathways. Whether transcription blockage contributes to the …

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in
homologous recombination-defective cancers by trap** PARP1 in a chromatin-bound …

Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …

The nucleoside analogue decitabine (or 5-aza-dC) is used to treat several haematological
cancers. Upon its triphosphorylation and incorporation into DNA, 5-aza-dC induces covalent …

Covalent DNA–protein cross-links (DPCs) are pervasive DNA lesions that challenge
genome stability and can be induced by metabolic or chemotherapeutic cross-linking agents …

Protein SUMOylation provides a principal driving force for cellular stress responses,
including DNA–protein crosslink (DPC) repair and arsenic-induced PML body degradation …