Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

Medical imaging has enormous potential for early disease prediction, but is impeded by the
difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to …

Alzheimer's disease (AD) is a degenerative neurological disease in elderly individuals.
Subjective cognitive decline (SCD), mild cognitive impairment (MCI) and further …

Research utilizing magnetic resonance imaging (MRI) has been crucial to the understanding
of the neuropathological mechanisms behind and clinical identification of Alzheimer's …

The world is aging and, as the elderly population increases, age-related cognitive decline
emerges as a major concern. Neuroimaging techniques, such as functional magnetic …

Understanding typical, healthy brain development provides a baseline from which to detect
and characterize brain anomalies associated with various neurological or psychiatric …

Cognition arises as a result of coordinated processing among distributed brain regions and
disruptions to communication within these neural networks can result in cognitive …

Abstract Properties of human brain tissue change across the lifespan. Here we model these
changes in the living human brain by combining quantitative magnetic resonance imaging …

Physical activity (PA) is known to maintain and improve neurocognitive health. However,
there is still a poor understanding of the mechanisms by which PA exerts its effects on the …