The contribution of evolutionary game theory to understanding and treating cancer

B Wölfl, H Te Rietmole, M Salvioli… - Dynamic Games and …, 2022 - Springer
Evolutionary game theory mathematically conceptualizes and analyzes biological
interactions where one's fitness not only depends on one's own traits, but also on the traits of …

In silico modelling of cancer nanomedicine, across scales and transport barriers

NR Stillman, M Kovacevic, I Balaz… - NPJ Computational …, 2020 - nature.com
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …

Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology

C Wu, G Lorenzo, DA Hormuth, EABF Lima… - Biophysics …, 2022 - pubs.aip.org
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

Patient-specific, mechanistic models of tumor growth incorporating artificial intelligence and big data

G Lorenzo, SR Ahmed, DA Hormuth II… - Annual Review of …, 2023 - annualreviews.org
Despite the remarkable advances in cancer diagnosis, treatment, and management over the
past decade, malignant tumors remain a major public health problem. Further progress in …

Theranostic digital twins: Concept, framework and roadmap towards personalized radiopharmaceutical therapies

H Abdollahi, F Yousefirizi, I Shiri, J Brosch-Lenz… - …, 2024 - pmc.ncbi.nlm.nih.gov
Radiopharmaceutical therapy (RPT) is a rapidly develo** field of nuclear medicine, with
several RPTs already well established in the treatment of several different types of cancers …

Image-based personalization of computational models for predicting response of high-grade glioma to chemoradiation

DA Hormuth, KA Al Feghali, AM Elliott, TE Yankeelov… - Scientific reports, 2021 - nature.com
High-grade gliomas are an aggressive and invasive malignancy which are susceptible to
treatment resistance due to heterogeneity in intratumoral properties such as cell proliferation …

[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

S Bekisz, L Geris - Journal of Computational Science, 2020 - Elsevier
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system

RA Bekker, S Kim, S Pilon-Thomas, H Enderling - Neoplasia, 2022 - Elsevier
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …

Zebrafish avatars towards personalized medicine—a comparative review between avatar models

B Costa, MF Estrada, RV Mendes, R Fior - Cells, 2020 - mdpi.com
Cancer frequency and prevalence have been increasing in the past decades, with
devastating impacts on patients and their families. Despite the great advances in targeted …