Museum of spatial transcriptomics
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …
tumors, depends on the spatial organization of their cells. In the past decade, high …
Spatial components of molecular tissue biology
Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …
evolving, making it possible to comprehensively characterize cells and tissues in health and …
Cell2location maps fine-grained cell types in spatial transcriptomics
Spatial transcriptomic technologies promise to resolve cellular wiring diagrams of tissues in
health and disease, but comprehensive map** of cell types in situ remains a challenge …
health and disease, but comprehensive map** of cell types in situ remains a challenge …
Inflammation in multiple sclerosis: Consequences for remyelination and disease progression
L Klotz, J Antel, T Kuhlmann - Nature Reviews Neurology, 2023 - nature.com
Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …
Spatial transcriptomics technology in cancer research
In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
A review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology
Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to-their cellular distribution in organisms has profound implications for …
work according to-their cellular distribution in organisms has profound implications for …
Decoding microRNAs in autism spectrum disorder
J Li, X Xu, J Liu, S Zhang, X Tan, Z Li, J Zhang… - … Therapy-Nucleic Acids, 2022 - cell.com
Autism spectrum disorder (ASD)—a congenital mental disorder accompanied by social
dysfunction and stereotyped behaviors—has attracted a great deal of attention worldwide. A …
dysfunction and stereotyped behaviors—has attracted a great deal of attention worldwide. A …
[HTML][HTML] Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer
The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is
susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing …
susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing …
The Emerging Roles of LIS 1 Biomechanics in Cellular and Cortical Homeostasis
A Kshirsagarand, O Reiner - Neocortical Neurogenesis in …, 2023 - Wiley Online Library
LIS1 (LISSENCEPHALY‐1, also known as PAFAH1B1) is the first gene identified and
reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 …
reported to be involved in neuronal migration. Multiple studies have demonstrated that LIS1 …
An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research
T Wang, K Harvey, J Reeves, DL Roden, N Bartonicek… - bioRxiv, 2023 - biorxiv.org
Background Spatial transcriptomic technologies are powerful tools for resolving the spatial
heterogeneity of gene expression in tissue samples. However, little evidence exists on …
heterogeneity of gene expression in tissue samples. However, little evidence exists on …