Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor
microenvironment. The main feature of these cells is their potent immune suppressive …

Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and
correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC …

Immune cells play a key role in host defense against infection and cancer. Upon
encountering danger signals, these cells undergo activation leading to a modulation in their …

Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different …

The generation of an inflammatory environment is favorable and often decisive for the
growth of both primary tumors and metastases. Tumor cells either express membrane …

Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T-cell
immunity and promoting malignant cell proliferation and migration. The therapeutic potential …