Similarities in neocortical circuit organization across areas and species suggest a common
strategy to process diverse types of information, including sensation from diverse modalities …

The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined
system for exploring the link between molecular mechanisms, synaptic circuits, and …

Genetically encoded calcium indicators (GECIs) can be used to image activity in defined
neuronal populations. However, current GECIs produce inferior signals compared to …

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse
functions. Although the striatum is thought to consist of sensorimotor, associative and limbic …

There has never been a wholesale way of identifying neurons that are monosynaptically
connected either to some other cell group or, especially, to a single cell. The best available …

Local microcircuits within neocortical columns form key determinants of sensory processing.
Here, we investigate the excitatory synaptic neuronal network of an anatomically defined …

Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …

In the rodent vibrissal system, active sensation and sensorimotor integration are mediated in
part by connections between barrel cortex and vibrissal motor cortex. Little is known about …

Neural computation involves diverse types of GABAergic inhibitory interneurons that are
integrated with excitatory (E) neurons into precisely structured circuits. To understand how …

Early sensory experience instructs the maturation of neural circuitry in the cortex,. This has
been studied extensively in the primary visual cortex, in which loss of vision to one eye …