The MutT proteins or “Nudix” hydrolases, a family of versatile, widely distributed,“housecleaning” enzymes

MJ Bessman, DN Frick, SF O'Handley - Journal of Biological Chemistry, 1996 - ASBMB
Our studies on the biochemical basis of spontaneous mutations took an interesting and
unexpected turn when we discovered that a small region of amino acid homology between …

The Nudix hydrolase superfamily

AG McLennan - Cellular and Molecular Life Sciences CMLS, 2006 - Springer
Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of
organic pyrophosphates, including nucleoside di-and triphosphates, dinucleoside and …

Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases

A Lonetti, Z Szijgyarto, D Bosch, O Loss… - Journal of Biological …, 2011 - ASBMB
Inorganic polyphosphate (poly-P) consists of just a chain of phosphate groups linked by high
energy bonds. It is found in every organism and is implicated in a wide variety of cellular …

[BOOK][B] Biological role of inorganic pyrophosphate

JK Heinonen - 2001 - books.google.com
Dr. Heinonen reviews and critically evaluates the scientific literature on the biological role of
inorganic pyrophosphate (PPi) published from 1940 to the end of 1999. He describes and …

Oxidative nucleotide damage: consequences and prevention

M Sekiguchi, T Tsuzuki - Oncogene, 2002 - nature.com
Oxoguanine (8-oxo-7, 8-dihydroguanine) is produced in DNA, as well as in nucleotide pools
of cells, by reactive oxygen species normally formed during cellular metabolic processes. 8 …

Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map

MKB Berlyn - Microbiology and Molecular Biology Reviews, 1998 - Am Soc Microbiol
This map is an update of the edition 9 map by Berlyn et al.(MKB Berlyn, KB Low, and KE
Rudd, p. 1715–1902, in FC Neidhardt et al., ed., Escherichia coli and Salmonella: cellular …

[HTML][HTML] A novel context for the 'MutT'module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase

ST Safrany, JJ Caffrey, X Yang, ME Bembenek… - The EMBO …, 1998 - embopress.org
Diphosphoinositol pentakisphosphate (PP‐InsP 5 or 'InsP 7') and bisdiphosphoinositol
tetrakisphosphate ([PP] 2‐InsP 4 or 'InsP 8') are the most highly phosphorylated members of …

Molecular genetics and structural biology of human MutT homolog, MTH1

Y Nakabeppu - … Research/Fundamental and Molecular Mechanisms of …, 2001 - Elsevier
The human MTH1 gene located on chromosome 7p22 consists of 5 major exons. MTH1
gene produces seven types of mRNAs and the B-type mRNAs with exon 2b–2c segments …

Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance

CA Dunn, SF O'Handley, DN Frick… - Journal of Biological …, 1999 - ASBMB
Four Nudix hydrolase genes, ysa1 fromSaccharomyces cerevisiae, orf209 fromEscherichia
coli, yqkg from Bacillus subtilis, and hi0398 from Hemophilus influenzae were amplified …

[HTML][HTML] Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis

D Avarbock, J Salem, L Li, Z Wang, H Rubin - Gene, 1999 - Elsevier
A 2.2 kb relA/spoT homologue was isolated from Mycobacterium tuberculosis (Mtb) genomic
DNA by PCR-amplification. The Mtb gene encodes a protein of 738 amino acid residues …