Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health
The human gut microbiome is a critical component of digestion, breaking down complex
carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract …
carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract …
Current enlightenment about etiology and pharmacological treatment of autism spectrum disorder
Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental brain disorder
characterized by two core behavioral symptoms, namely impairments in social …
characterized by two core behavioral symptoms, namely impairments in social …
Gut microbiota role in dietary protein metabolism and health-related outcomes: The two sides of the coin
KJ Portune, M Beaumont, AM Davila, D Tomé… - Trends in Food Science …, 2016 - Elsevier
Background Human gut bacteria can synthesize proteinogenic amino acids and produce a
range of metabolites via protein fermentation, some known to exert beneficial or harmful …
range of metabolites via protein fermentation, some known to exert beneficial or harmful …
Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases
The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …
Amyotrophic lateral sclerosis and autophagy: dysfunction and therapeutic targeting
Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …
Role of neuroinflammation in autism spectrum disorder and the emergence of brain histaminergic system. Lessons also for BPSD?
Many behavioral and psychological symptoms of dementia (BPSD) share similarities in
executive functioning and communication deficits with those described in several …
executive functioning and communication deficits with those described in several …
Altered expression of histamine signaling genes in autism spectrum disorder
C Wright, JH Shin, A Rajpurohit… - Translational …, 2017 - nature.com
The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors.
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …
New developments in the management of narcolepsy
VC Abad, C Guilleminault - Nature and science of sleep, 2017 - Taylor & Francis
Narcolepsy is a life-long, underrecognized sleep disorder that affects 0.02%–0.18% of the
US and Western European populations. Genetic predisposition is suspected because of …
US and Western European populations. Genetic predisposition is suspected because of …
Hypothalamic tuberomammillary nucleus neurons: electrophysiological diversity and essential role in arousal stability
Histaminergic (HA) neurons, found in the posterior hypothalamic tuberomammillary nucleus
(TMN), extend fibers throughout the brain and exert modulatory influence over numerous …
(TMN), extend fibers throughout the brain and exert modulatory influence over numerous …
Pathophysiological studies of monoaminergic neurotransmission systems in valproic acid-induced model of autism spectrum disorder
HY Kuo, FC Liu - Biomedicines, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex etiology.
The core syndromes of ASD are deficits in social communication and self-restricted interests …
The core syndromes of ASD are deficits in social communication and self-restricted interests …