Metabolism and growth adaptation to environmental conditions in Drosophila

T Koyama, MJ Texada, KA Halberg… - Cellular and Molecular Life …, 2020 - Springer
Organisms adapt to changing environments by adjusting their development, metabolism,
and behavior to improve their chances of survival and reproduction. To achieve such …

Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly

H Li, J Janssens, M De Waegeneer, SS Kolluru… - Science, 2022 - science.org
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

SK Kim, DD Tsao, GSB Suh, I Miguel-Aliaga - Cell metabolism, 2021 - cell.com
There has been rapid growth in the use of Drosophila and other invertebrate systems to
dissect mechanisms governing metabolism. New assays and approaches to physiology …

High-resolution 3D spatiotemporal transcriptomic maps of develo** Drosophila embryos and larvae

M Wang, Q Hu, T Lv, Y Wang, Q Lan, R **ang, Z Tu… - Developmental Cell, 2022 - cell.com
Drosophila has long been a successful model organism in multiple biomedical fields. Spatial
gene expression patterns are critical for the understanding of complex pathways and …

A nutrient-specific gut hormone arbitrates between courtship and feeding

HH Lin, MC Kuang, I Hossain, Y Xuan, L Beebe… - Nature, 2022 - nature.com
Animals must set behavioural priority in a context-dependent manner and switch from one
behaviour to another at the appropriate moment,–. Here we probe the molecular and …

A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila

A Malita, O Kubrak, T Koyama, N Ahrentløv… - Nature …, 2022 - nature.com
Animals must adapt their dietary choices to meet their nutritional needs. How these needs
are detected and translated into nutrient-specific appetites that drive food-choice behaviours …

A phosphate-sensing organelle regulates phosphate and tissue homeostasis

C Xu, J Xu, HW Tang, M Ericsson, JH Weng, J DiRusso… - Nature, 2023 - nature.com
Inorganic phosphate (Pi) is one of the essential molecules for life. However, little is known
about intracellular Pi metabolism and signalling in animal tissues. Following the observation …

Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut

A Petsakou, Y Liu, Y Liu, A Comjean, Y Hu, N Perrimon - Nature, 2023 - nature.com
A fundamental and unresolved question in regenerative biology is how tissues return to
homeostasis after injury. Answering this question is essential for understanding the …

FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas

SA Krause, G Overend, JAT Dow… - Nucleic Acids …, 2022 - academic.oup.com
Abstract FlyAtlas 2 (flyatlas2. org) is a database and web application for studying the
expression of the genes of Drosophila melanogaster in different tissues of adults and larvae …

The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster

Y Yoshinari, H Kosakamoto, T Kamiyama… - Nature …, 2021 - nature.com
The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the
secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like …