More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

Adeno-associated viral (AAV) vectors have emerged as the leading gene delivery platform
for gene therapy and vaccination. Three AAV-based gene therapy drugs, Glybera …

Construction of a complex virus may involve a hierarchy of assembly elements. Here, we
report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by …

Rational development of adenovirus vectors for therapeutic gene transfer is hampered by
the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom …

Adenovirus (AdV) capsid organization is considerably complex, not only because of its large
size (~ 950 Å) and triangulation number (pseudo T= 25), but also because it contains four …

Viral particle binding to plasma membrane receptors elicits virus motions, recruits signaling
proteins, and triggers membrane bending and fission, finally resulting in endocytic virus …

Here we review the current knowledge on maturation of adenovirus, a non-enveloped
icosahedral eukaryotic virus. The adenovirus dsDNA genome fills the capsid in complex with …

A detailed structural analysis of the entire human adenovirus capsid has been stymied by
the complexity and size of this 150 MDa macromolecular complex. Over the past 10 years …

Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing
goal in the field of clinical gene therapy. To achieve this, platform vectors must combine …

Tight confinement of naked genomes within some viruses results in high internal pressure
that facilitates their translocation into the host. Adenovirus, however, encodes histone-like …