Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …

Significant resources in early drug discovery are spent unknowingly pursuing artifacts and
promiscuous bioactive compounds, while understanding the chemical basis for these …

Enzymes are common targets in high-throughput screening and related campaigns. An
analysis of papers published between 1990 and 2018 showed that kinases were the most …

Matching the power of high throughput screening to the chemical diversity of natural products -
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …

As our understanding of diseases deepens, increasing therapeutic targets are being
identified, which facilitates the development of new drug candidates. However, drug …

Although small-molecule drug discovery efforts have focused largely on enzyme, receptor,
and ion-channel targets, there has been an increase in such activities to search for protein …

Natural small molecules derived from plants have fascinated scientists for centuries due to
their practical applications in various fields, especially in nanomedicine. Some of the natural …

The US federal consortium on toxicology in the 21st century (Tox21) produces quantitative,
high-throughput screening (HTS) data on thousands of chemicals across a wide range of …

Selective kinase inhibitors development is a cumbersome task because of ATP binding sites
similarities across kinases. On contrast, irreversible allosteric covalent inhibition offers …