Elastin‐like polypeptides: biomedical applications of tunable biopolymers

SR MacEwan, A Chilkoti - Peptide Science: Original Research …, 2010 - Wiley Online Library
Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

Biomimetic scaffolds for tissue engineering

TG Kim, H Shin, DW Lim - Advanced Functional Materials, 2012 - Wiley Online Library
Biomimetic scaffolds mimic important features of the extracellular matrix (ECM) architecture
and can be finely controlled at the nano‐or microscale for tissue engineering. Rational …

Aromatic− aromatic interactions induce the self-assembly of pentapeptidic derivatives in water to form nanofibers and supramolecular hydrogels

M Ma, Y Kuang, Y Gao, Y Zhang, P Gao… - Journal of the American …, 2010 - ACS Publications
In this paper we report the conjugation of an aromatic moiety (pyrene (P), fluorene (F), or
naphthalene (N)) to pentapeptides GAGAS (1), GVPVP (2), VPGVG (3), VTEEI (4), VYGGG …

Peptide-based biopolymers in biomedicine and biotechnology

D Chow, ML Nunalee, DW Lim, AJ Simnick… - Materials Science and …, 2008 - Elsevier
Peptides are emerging as a new class of biomaterials due to their unique chemical,
physical, and biological properties. The development of peptide-based biomaterials is …

Challenges and opportunities in the purification of recombinant tagged proteins

AS Pina, CR Lowe, ACA Roque - Biotechnology advances, 2014 - Elsevier
The purification of recombinant proteins by affinity chromatography is one of the most
efficient strategies due to the high recovery yields and purity achieved. However, this is …

Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides

JA MacKay, DJ Callahan, KN FitzGerald… - …, 2010 - ACS Publications
Quantitative models are required to engineer biomaterials with environmentally responsive
properties. With this goal in mind, we developed a model that describes the pH-dependent …

Predicting transition temperatures of elastin-like polypeptide fusion proteins

T Christensen, W Hassouneh… - …, 2013 - ACS Publications
Elastin-like polypeptides (ELPs) are thermally sensitive peptide polymers that undergo
thermally triggered phase separation and this behavior is imparted to soluble proteins when …

Secondary structure formation and LCST behavior of short elastin-like peptides

H Nuhn, HA Klok - Biomacromolecules, 2008 - ACS Publications
This contribution investigates the effects of chain length and chemical composition on the
secondary structure and LCST behavior of a library of short, elastin-like peptides based on …

In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair

DW Lim, DL Nettles, LA Setton, A Chilkoti - Biomacromolecules, 2008 - ACS Publications
Rapid cross-linking of elastin-like polypeptides (ELPs) with hydroxymethylphosphines
(HMPs) in aqueous solution is attractive for minimally invasive in vivo implantation of …