Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (eg,
tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural …

Preterm birth is the leading cause of mortality in children under the age of five worldwide.
Despite major efforts, we still lack the ability to accurately predict and effectively prevent …

The male reproductive system, particularly the male gamete, offers a unique barrier to the
immune system. The growing germ cells in the testis need to be shielded from autoimmune …

The physiological process of male reproduction relies on the orchestration of
neuroendocrine, immune, and energy metabolism. Spermatogenesis is controlled by the …

The intrauterine environment is an important determinant of immunity later in life of the
offspring. An altered prenatal immune development can result in a high postnatal risk for …

Mother-to-child transmission is the major cause of chronic hepatitis B virus (HBV) infection.
This double-blind trial tested the effect of tenofovir disoproxil fumarate (TDF) in preventing …

Introduction Biological rhythms, the innate cycle of changes in the body's physiological
functions, are circadian if they have a 24‐hour period. It is known that sleep is a key feature …

During female lifetime and pregnancy, inflammation and cellular senescence are implicated
in physiological processes, from ovulation and menstruation, to placental homeostasis and …

Maternal obesity has been associated with short-and long-term risks of pregnancy-perinatal
adverse events, possibly due to alterations of placental mitochondrial bioenergetics …

Introduction Postpartum mood disorders are heterogenous disorders and comprise
postpartum psychosis and postpartum depression. Evidence is accumulating that systemic …