Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

It is remarkable how robustly a bacterial species can maintain its preferred size. This
capacity is intimately related to control of the cell cycle: cell size and growth rate determine …

Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays
in dynamic, living systems. A major critical challenge for this class of experiments is the …

Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …

INTRODUCTION The generation of biological data is presenting us with one of the most
demanding analysis challenges the world has ever faced, not only in terms of storage and …

Many studies have focused on the mechanisms underlying length and width determination
in rod-shaped bacteria. Here, we focus instead on cell surface area to volume ratio (SA/V) …

Many experiments show that the numbers of mRNA and protein are proportional to the cell
volume in growing cells. However, models of stochastic gene expression often assume …

It is widely acknowledged that faster-growing bacteria are killed faster by β-lactam
antibiotics. This notion serves as the foundation for the concept of bacterial persistence …

Cell size and growth kinetics are fundamental cellular properties with important
physiological implications. Classical studies on yeast, and recently on bacteria, have …

Cell size varies during the cell cycle and in response to external stimuli. This requires the
tight coordination, or" scaling," of mRNA and protein quantities with the cell volume in order …