A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists
MC Michel, C Foster, HR Brunner, L Liu… - Pharmacological …, 2013 - Elsevier
Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …
In silico pharmacology for drug discovery: applications to targets and beyond
Computational (in silico) methods have been developed and widely applied to
pharmacology hypothesis development and testing. These in silico methods include …
pharmacology hypothesis development and testing. These in silico methods include …
DrugBank: a knowledgebase for drugs, drug actions and drug targets
DS Wishart, C Knox, AC Guo, D Cheng… - Nucleic acids …, 2008 - academic.oup.com
DrugBank is a richly annotated resource that combines detailed drug data with
comprehensive drug target and drug action information. Since its first release in 2006 …
comprehensive drug target and drug action information. Since its first release in 2006 …
The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases
All national guidelines for the management of hypertension recommend angiotensin
receptor blockers (ARBs) as an initial or add-on antihypertensive therapy. The eight …
receptor blockers (ARBs) as an initial or add-on antihypertensive therapy. The eight …
In silico repositioning of approved drugs for rare and neglected diseases
One approach to speed up drug discovery is to examine new uses for existing approved
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …
Design, synthesis, cytoselective toxicity, structure–activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells
H Zhou, S Wu, S Zhai, A Liu, Y Sun, R Li… - Journal of Medicinal …, 2008 - ACS Publications
Ten cytoselective compounds have been identified from 372 thiazolidinone analogues by
applying iterative library approaches. These compounds selectively killed both non-small …
applying iterative library approaches. These compounds selectively killed both non-small …
ADME evaluation in drug discovery. 10. Predictions of P-glycoprotein inhibitors using recursive partitioning and naive Bayesian classification techniques
L Chen, Y Li, Q Zhao, H Peng, T Hou - Molecular pharmaceutics, 2011 - ACS Publications
P-Glycoprotein (P-gp), an efflux transporter, plays a crucial role in drug pharmacokinetic
properties (ADME), and is critical for multidrug resistance (MDR) by mediating the active …
properties (ADME), and is critical for multidrug resistance (MDR) by mediating the active …
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …
effecting drug uptake into cells, and questions that transporters can recognize drug …
Structure–activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP)
The hepatic bile acid uptake transporter sodium taurocholate cotransporting polypeptide
(NTCP) is less well characterized than its ileal paralog, the apical sodium dependent bile …
(NTCP) is less well characterized than its ileal paralog, the apical sodium dependent bile …
An updated patent review on P-glycoprotein inhibitors (2011-2018)
M Leopoldo, P Nardulli, M Contino… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: P-glycoprotein is a complex ATP-ase transporter involved in physiological and
pathological functions. In particular, it is involved in the onset of multidrug resistance in …
pathological functions. In particular, it is involved in the onset of multidrug resistance in …