Nonhuman primate optogenetics: recent advances and future directions
Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for
millisecond resolution control of neural activity. By targeting opsin expression to specific cell …
millisecond resolution control of neural activity. By targeting opsin expression to specific cell …
The phasic dopamine signal maturing: from reward via behavioural activation to formal economic utility
Highlights•Two-component dopamine response structure explains lack of activation by
aversiveness.•Other phasic dopamine changes reflect behavioural activation.•Dopamine …
aversiveness.•Other phasic dopamine changes reflect behavioural activation.•Dopamine …
A map of object space in primate inferotemporal cortex
The inferotemporal (IT) cortex is responsible for object recognition, but it is unclear how the
representation of visual objects is organized in this part of the brain. Areas that are selective …
representation of visual objects is organized in this part of the brain. Areas that are selective …
Noninvasive optical inhibition with a red-shifted microbial rhodopsin
Optogenetic inhibition of the electrical activity of neurons enables the causal assessment of
their contributions to brain functions. Red light penetrates deeper into tissue than other …
their contributions to brain functions. Red light penetrates deeper into tissue than other …
[HTML][HTML] An open resource for non-human primate optogenetics
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …
animal models more closely related to humans, such as non-human primates (NHPs), has …
Minimally invasive multimode optical fiber microendoscope for deep brain fluorescence imaging
A major open challenge in neuroscience is the ability to measure and perturb neural activity
in vivo from well defined neural sub-populations at cellular resolution anywhere in the brain …
in vivo from well defined neural sub-populations at cellular resolution anywhere in the brain …
[HTML][HTML] Dopamine neuron-specific optogenetic stimulation in rhesus macaques
Optogenetic studies in mice have revealed new relationships between well-defined neurons
and brain functions. However, there are currently no means to achieve the same cell-type …
and brain functions. However, there are currently no means to achieve the same cell-type …
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system
Optogenetics offers promise for dissecting the complex neural circuits of the spinal cord and
peripheral nervous system and has therapeutic potential for addressing unmet clinical …
peripheral nervous system and has therapeutic potential for addressing unmet clinical …
[HTML][HTML] Combining brain perturbation and neuroimaging in non-human primates
Brain perturbation studies allow detailed causal inferences of behavioral and neural
processes. Because the combination of brain perturbation methods and neural …
processes. Because the combination of brain perturbation methods and neural …
Electrode materials for chronic electrical microstimulation
Electrical microstimulation has enabled partial restoration of vision, hearing, movement,
somatosensation, as well as improving organ functions by electrically modulating neural …
somatosensation, as well as improving organ functions by electrically modulating neural …