Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

The employment of light and/or electricity–alternatively to conventional thermal energy–
unlocks new reactivity paradigms as tools for chemical substrate activations. This leads to …

Much progress has been made in the development of methods to both create compounds
that contain C− F bonds and to functionalize C− F bonds. As such, C− F bonds are becoming …

This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …

Decarboxylative protonation is a general deletion tactic to replace polar carboxylic acid
groups with hydrogen or its isotope. Current methods rely on the pre‐activation of acids, non …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Herein, we report a photoinduced approach for hydroarylation of unactivated olefins using 4‐
hydroxycoumarins as the arylating reagent. Key to the success of this reaction is the …

To avoid the harsh conditions that are oftentimes adopted in direct radiofluorination
reactions, conjugation of bioactive ligands with 18F-labeled prosthetic groups has become …

In this study, we introduce a practical methodology for the synthesis of PET probes by
seamlessly combining flow chemistry with photoredox radiofluorination. The clinical PET …

This review discusses recent advances in light‐driven radiochemistry for three key isotopes:
fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission …