Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria
Antimicrobial peptides (AMPs) are short peptidic molecules produced by most living
creatures. They help unicellular organisms to successfully compete for nutrients with other …
creatures. They help unicellular organisms to successfully compete for nutrients with other …
The skin microbiome: current landscape and future opportunities
P Smythe, HN Wilkinson - International journal of molecular sciences, 2023 - mdpi.com
Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …
extrinsic environment. Alongside preventing desiccation, chemical damage and …
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …
associated with disorders such as inflammatory bowel disease, pathogen infection and …
Cationic peptides: a new source of antibiotics
Antimicrobial cationic peptides are an important component of the innate defenses of all
species of life. Different peptides may have antibacterial, antiendotoxic, antibiotic …
species of life. Different peptides may have antibacterial, antiendotoxic, antibiotic …
Isolation and characterization of human μ-Defensin-3, a novel human inducible peptide antibiotic
J Harder, J Bartels, E Christophers… - Journal of Biological …, 2001 - ASBMB
The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …
A peptide antibiotic from human skin
J Harder, J Bartels, E Christophers, JM Schröder - Nature, 1997 - nature.com
To avoid opportunistic infections, plants and animals have developed antimicrobial peptides
in their epithelia that can form pores in the cytoplasmic membrane of microorganisms. After …
in their epithelia that can form pores in the cytoplasmic membrane of microorganisms. After …
Human antimicrobial peptides and proteins
G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …
Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37
The influence of ion composition, pH, and peptide concentration on the conformation and
activity of the 37-residue human antibacterial peptide LL-37 has been studied. At micromolar …
activity of the 37-residue human antibacterial peptide LL-37 has been studied. At micromolar …
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial
E Furrie, S Macfarlane, A Kennedy, JH Cummings… - Gut, 2005 - gut.bmj.com
Background and aims: Ulcerative colitis (UC) is an acute and chronic inflammatory disease
of the large bowel with unknown aetiology. The immune response against normal …
of the large bowel with unknown aetiology. The immune response against normal …
The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations
B Agerberth, J Charo, J Werr, B Olsson… - Blood, The Journal …, 2000 - ashpublications.org
We identified antibacterial components in human T and natural killer (NK) cells by using
freshly isolated lymphocytes enriched for T and NK cells as starting material. After growing …
freshly isolated lymphocytes enriched for T and NK cells as starting material. After growing …