Molecular biomarkers in prostate cancer tumorigenesis and clinical relevance

NO Alqualo, E Campos-Fernandez, BU Picolo… - Critical Reviews in …, 2024 - Elsevier
Prostate cancer (PCa) is the second most frequent type of cancer in men and assessing
circulating tumor cells (CTCs) by liquid biopsy is a promising tool to help in cancer early …

The significant others of aurora kinase a in cancer: combination is the key

K Nikhil, K Shah - Biomarker Research, 2024 - Springer
AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also
established its critical role in a plethora of other biological processes including ciliogenesis …

Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model

S Wagner, SL Whiteley, M Castelli, HR Patel… - BMC genomics, 2023 - Springer
Background Sex determination is the process whereby the bipotential embryonic gonads
become committed to differentiate into testes or ovaries. In genetic sex determination (GSD) …

Fast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei using Microwell-seq3

F Ye, S Zhang, Y Fu, L Yang, G Zhang, Y Wu, J Pan… - Cell Discovery, 2024 - nature.com
Single cell chromatin accessibility profiling and transcriptome sequencing are the most
widely used technologies for single-cell genomics. Here, we present Microwell-seq3, a high …

Variants in interferon gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes that modulate inflammatory response are associated with …

MO Barrientos, ÁA Cruz, HMP Teixeira… - Archives of Oral …, 2023 - Elsevier
Objective Evaluate the association of genetic variants of the interferon gamma inducible
protein 16 (IFI16) and absent in melanoma 2 (AIM2) genes with periodontitis. Methods The …

Emerging Therapeutic Frontiers in Prostate Health: Novel Molecular Targets and Classical Pathways in comparison with BPH and Prostate Cancer

MS Hassan, HM Irfan, M Sarwar, Z Jabbar… - Critical Reviews in …, 2024 - Elsevier
Current therapeutic strategies for benign prostatic hyperplasia (BPH) and prostate cancer
focus mainly on androgen receptors (AR) and 5-alpha reductase inhibition to suppress …

Radiogenomics Map-Based Molecular and Imaging Phenotypical Characterization in Localised Prostate Cancer Using Pre-Biopsy Biparametric MR Imaging

CN Ogbonnaya, BSO Alsaedi, AJ Alhussaini… - International Journal of …, 2024 - mdpi.com
To create a radiogenomics map and evaluate the correlation between molecular and
imaging phenotypes in localized prostate cancer (PCa), using radical prostatectomy …

Anticancer activities of Brachydin C in human prostate tumor cells (DU145) grown in 2D and 3D models: Stimulation of cell death and downregulation of …

LCB Oliveira, DL Ribeiro… - Chemical Biology & …, 2022 - Wiley Online Library
Brachydin C (BrC) has demonstrated in vitro cytotoxic and antiproliferative effects in prostate
cancer cells. In the present study, we compare the anticancer effects of BrC in DU145 cells …

Potential role of exitron‐containing homeobox genes in cancer

J de Faria Poloni, BC Feltes - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Homeobox genes are protagonists in developmental and cancer biology, making
comprehending their regulation pivotal in multiple molecular pathways. Exitrons, also known …

Genetic, Genomic, and Heritable Components of Benign Prostatic Hyperplasia

AM Makedon, SX Sempson, P Hargis… - Current Bladder …, 2023 - Springer
Abstract Purpose of Review While BPH, and the complications that follow, represents the
largest cause of urologic suffering both in the USA and globally, the underlying causes …