Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …

Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …

Cardiomyopathies have unresolved genotype–phenotype relationships and lack disease-
specific treatments. Here we provide a framework to identify genotype-specific …

Rationale: Calcium transient analysis is central to understanding inherited and acquired
cardiac physiology and disease. Although the development of novel calcium reporters …

Abstract Mechano-electric feedbacks (MEFs), which model how mechanical stimuli are
transduced into electrical signals, have received sparse investigation by considering …