Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

[HTML][HTML] Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management

B Singh, CM Day, S Abdella, S Garg - Journal of Controlled Release, 2024 - Elsevier
Abstract Alzheimer's disease (AD), is a neurodegenerative disorder that escalates with time,
exerting a significant impact on physical and mental health and leading to death. The …

[HTML][HTML] Amyloid precursor protein and Alzheimer's disease

KS Orobets, AL Karamyshev - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late …

Nanozyme‐Based Regulation of Cellular Metabolism and Their Applications

Y Wang, X Jia, S An, W Yin, J Huang… - Advanced …, 2024 - Wiley Online Library
Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

Revitalizing ancient mitochondria with nano‐strategies: mitochondria‐remedying nanodrugs concentrate on disease control

X Long, M Liu, Y Nan, Q Chen, Z **ao… - Advanced …, 2024 - Wiley Online Library
Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital
functions across diverse cellular processes. Dysfunctions within mitochondria serve as …

Emerging strategies to fabricate polymeric nanocarriers for enhanced drug delivery across blood-brain barrier: an overview

YH Song, R De, KT Lee - Advances in Colloid and Interface Science, 2023 - Elsevier
Blood-brain barrier (BBB) serves as an essential interface between central nervous system
(CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and …

Prussian blue nanozymes: progress, challenges, and opportunities

H He, M Long, Y Duan, N Gu - Nanoscale, 2023 - pubs.rsc.org
Prussian Blue Nanozymes (PBNZs) have emerged as highly efficient agents for reactive
oxygen species (ROS) elimination, owing to their multiple enzyme-like properties …

Multivalent Nanobody conjugate with rigid, reactive oxygen species scavenging scaffold for multi‐target therapy of Alzheimer's disease

L Zhao, F Meng, Y Li, S Liu, M Xu, F Chu… - Advanced …, 2023 - Wiley Online Library
Efficient therapeutic strategies that concurrently target both Aβ aggregation and oxidative
stress in the Alzheimer's disease (AD) microenvironment emerge as a cutting‐edge tool to …

Black Phosphorus Nanosheets Protect Neurons by Degrading Aggregative α‐syn and Clearing ROS in Parkinson's Disease

M He, X Zhang, X Ran, Y Zhang, X Nie… - Advanced …, 2024 - Wiley Online Library
Although evidence indicates that the abnormal accumulation of α‐synuclein (α‐syn) in
dopamine neurons of the substantia nigra is the main pathological feature of Parkinson's …

Emerging nanotechnology for Alzheimer's disease: From detection to treatment

N Song, S Sun, K Chen, Y Wang, H Wang… - Journal of Controlled …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), one of the most common chronic neurodegenerative
diseases, is characterized by memory impairment, synaptic dysfunction, and character …