Mathematical modeling of tumor-immune cell interactions

GE Mahlbacher, KC Reihmer, HB Frieboes - Journal of Theoretical Biology, 2019‏ - Elsevier
The anti-tumor activity of the immune system is increasingly recognized as critical for the
mounting of a prolonged and effective response to cancer growth and invasion, and for …

A decade of thermostatted kinetic theory models for complex active matter living systems

C Bianca - Physics of Life Reviews, 2024‏ - Elsevier
In the last decade, the thermostatted kinetic theory has been proposed as a general
paradigm for the modeling of complex systems of the active matter and, in particular, in …

Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression

RJ Seager, C Hajal, F Spill, RD Kamm… - Convergent science …, 2017‏ - iopscience.iop.org
In the tumour microenvironment, cancer cells directly interact with both the immune system
and the stroma. It is firmly established that the immune system, historically believed to be a …

Modeling the dynamics of tumor–immune cells interactions via fractional calculus

TQ Tang, Z Shah, R Jan, E Alzahrani - The European Physical Journal …, 2022‏ - Springer
The immune response in the tumor micro-environment is a complicated biological
phenomenon that needs to be investigated further. It is eminent that tumor is murderous and …

The influence of time delay in a chaotic cancer model

S Khajanchi, M Perc, D Ghosh - Chaos: An Interdisciplinary Journal of …, 2018‏ - pubs.aip.org
The tumor-immune interactive dynamics is an evergreen subject that continues to draw
attention from applied mathematicians and oncologists, especially so due to the …

A time delay model of tumour–immune system interactions: Global dynamics, parameter estimation, sensitivity analysis

FA Rihan, DHA Rahman, S Lakshmanan… - Applied Mathematics …, 2014‏ - Elsevier
Recently, a large number of mathematical models that are described by delay differential
equations (DDEs) have appeared in the life sciences. In this paper, we present a delay …

[HTML][HTML] Optimal control of variable-order fractional model for delay cancer treatments

NH Sweilam, SM Al-Mekhlafi, AO Albalawi… - Applied Mathematical …, 2021‏ - Elsevier
This article presents a fractional-order mathematical model of the biological phenomena that
occur in cancer therapy. The formulation generalizes the one proposed by Soto-Ortiza and …

Mathematical modeling of tumor-immune competitive system, considering the role of time delay

S Khajanchi, JJ Nieto - Applied mathematics and computation, 2019‏ - Elsevier
In this paper, we consider a three-dimensional nonlinear delay differential system (tumor
cells, cytotoxic-T lymphocytes, T-helper cells) with single interaction delay. We perform …

How tumor growth can be influenced by delayed interactions between cancer cells and the microenvironment?

D Ghosh, S Khajanchi, S Mangiarotti, F Denis… - BioSystems, 2017‏ - Elsevier
Although recent advances in oncology emphasized the role of microenvironment in tumor
growth, the role of delays for modeling tumor growth is still uncertain. In this paper, we …

[HTML][HTML] Nonlinear dynamics in tumor-immune system interaction models with delays

S Ruan - Discrete and Continuous Dynamical Systems-B, 2021‏ - aimsciences.org
In this paper, we review some recent results on the nonlinear dynamics of delayed
differential equation models describing the interaction between tumor cells and effector cells …