Enzyme-Instructed Intracellular Peptide Assemblies

Z Liu, J Guo, Y Qiao, B Xu - Accounts of chemical research, 2023 - ACS Publications
Conspectus Higher-order or supramolecular protein assemblies, usually regulated by
enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary …

Therapeutic supramolecular polymers: Designs and applications

H Wang, J Mills, B Sun, H Cui - Progress in polymer science, 2024 - Elsevier
The self-assembly of low-molecular-weight building motifs into supramolecular polymers
has unlocked a new realm of materials with distinct properties and tremendous potential for …

Utilizing the hofmeister effect to induce hydrogelation of nonionic supramolecular polymers into a therapeutic depot

H Wang, H Su, T Xu, H Cui - Angewandte Chemie International …, 2023 - Wiley Online Library
Nonionic hydrogels are of particular interest for long‐term therapeutic implantation due to
their minimal immunogenicity relative to their charged counterparts. However, in situ …

Constructing antiretroviral supramolecular polymers as Long-acting Injectables through rational Design of Drug Amphiphiles with alternating antiretroviral-based and …

H Wang, MK Monroe, F Wang, M Sun… - Journal of the …, 2023 - ACS Publications
One of the main challenges in the development of long-acting injectables for HIV treatment
is the limited duration of drug release, which results in the need for frequent dosing and …

Recent advances in biomimetic strategies for the immunotherapy of glioblastoma

H You, S Geng, S Li, M Imani, D Brambilla, T Sun… - Biomaterials, 2024 - Elsevier
Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …

Peptide‐based supramolecular therapeutics for fighting major diseases

Z Wang, H Luo, H Wang, M **ao, H Jia… - Advanced Functional …, 2024 - Wiley Online Library
Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines
based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo …

Autohydrolysis of Diglycine‐Activated Succinic Esters Boosts Cellular Uptake

J Guo, W Tan, H He, B Xu - Angewandte Chemie International …, 2023 - Wiley Online Library
Rapid cellular uptake of synthetic molecules remains a challenge, and the motif frequently
employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the …

Engineering disease analyte response in peptide self-assembly

S Yu, MJ Webber - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
A need to enhance the precision and specificity of therapeutic nanocarriers inspires the
development of advanced nanomaterials capable of sensing and responding to disease …

Personalized Nanovaccines Enhance Lymph Node Accumulation and Reprogram the Tumor Microenvironment for Improved Photodynamic Immunotherapy

R Wang, J Li, X Wang, Y Zhang, A Zhu, K Feng, J Li… - Nano …, 2024 - ACS Publications
Tumor immunotherapy has emerged as an efficacious therapeutic approach that mobilizes
the patient's immune system to achieve durable tumor suppression. Here, we design a …

Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment

X Deng, X Sun, Z Hu, Y Wu, C Zhou, J Sun… - The FASEB …, 2023 - Wiley Online Library
Although the role of N6‐Methyladenosine (m6A) methylation factors has been established in
multiple cancer types, its involvement in glioblastoma multiforme (GBM) remains limited …