Enzyme-Instructed Intracellular Peptide Assemblies
Conspectus Higher-order or supramolecular protein assemblies, usually regulated by
enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary …
enzymatic reactions, are ubiquitous and essential for cellular functions. This evolutionary …
Therapeutic supramolecular polymers: Designs and applications
The self-assembly of low-molecular-weight building motifs into supramolecular polymers
has unlocked a new realm of materials with distinct properties and tremendous potential for …
has unlocked a new realm of materials with distinct properties and tremendous potential for …
Utilizing the hofmeister effect to induce hydrogelation of nonionic supramolecular polymers into a therapeutic depot
Nonionic hydrogels are of particular interest for long‐term therapeutic implantation due to
their minimal immunogenicity relative to their charged counterparts. However, in situ …
their minimal immunogenicity relative to their charged counterparts. However, in situ …
Constructing antiretroviral supramolecular polymers as Long-acting Injectables through rational Design of Drug Amphiphiles with alternating antiretroviral-based and …
One of the main challenges in the development of long-acting injectables for HIV treatment
is the limited duration of drug release, which results in the need for frequent dosing and …
is the limited duration of drug release, which results in the need for frequent dosing and …
Recent advances in biomimetic strategies for the immunotherapy of glioblastoma
Immunotherapy is regarded as one of the most promising approaches for treating tumors,
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …
with a multitude of immunotherapeutic thoughts currently under consideration for the lethal …
Peptide‐based supramolecular therapeutics for fighting major diseases
Z Wang, H Luo, H Wang, M **ao, H Jia… - Advanced Functional …, 2024 - Wiley Online Library
Peptide‐based supramolecular therapeutics (PST) refer to those theranostic nanomedicines
based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo …
based on peptide or peptide derivatives self‐assembly that are constructed in vitro or in vivo …
Autohydrolysis of Diglycine‐Activated Succinic Esters Boosts Cellular Uptake
Rapid cellular uptake of synthetic molecules remains a challenge, and the motif frequently
employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the …
employed to generate prodrugs, succinic ester, unfortunately lowers the efficacy of the …
Engineering disease analyte response in peptide self-assembly
A need to enhance the precision and specificity of therapeutic nanocarriers inspires the
development of advanced nanomaterials capable of sensing and responding to disease …
development of advanced nanomaterials capable of sensing and responding to disease …
Personalized Nanovaccines Enhance Lymph Node Accumulation and Reprogram the Tumor Microenvironment for Improved Photodynamic Immunotherapy
R Wang, J Li, X Wang, Y Zhang, A Zhu, K Feng, J Li… - Nano …, 2024 - ACS Publications
Tumor immunotherapy has emerged as an efficacious therapeutic approach that mobilizes
the patient's immune system to achieve durable tumor suppression. Here, we design a …
the patient's immune system to achieve durable tumor suppression. Here, we design a …
Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment
X Deng, X Sun, Z Hu, Y Wu, C Zhou, J Sun… - The FASEB …, 2023 - Wiley Online Library
Although the role of N6‐Methyladenosine (m6A) methylation factors has been established in
multiple cancer types, its involvement in glioblastoma multiforme (GBM) remains limited …
multiple cancer types, its involvement in glioblastoma multiforme (GBM) remains limited …