Oesophageal cancer is the sixth most common cause of cancer-related death worldwide
and is therefore a major global health challenge. The two major subtypes of oesophageal …

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a
stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy …

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells
compete for space and resources, evade predation by the immune system and can even …

The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its
precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome …

Barrett's esophagus (BE) is a common condition, and is the precursor to esophageal
adenocarcinoma, a disease with increasing burden in the western world, especially in …

The aim of evidence-based medicine is to improve the quality of health care by integrating
the best research evidence with clinical expertise and patient values. Evidence-based …

The guidelines for the diagnosis, surveillance and therapy of Barrett's esophagus were
originally published by the American College of Gastroenterology in 1998 and updated in …

Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis
by many years,,–. We assess whether these genomic signals can be used for early detection …

Neoplasms are thought to progress to cancer through genetic instability generating cellular
diversity, and clonal expansions driven by selection for mutations in cancer genes,. Despite …