Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

A major obstacle for chimeric antigen receptor (CAR) T cell therapy in solid tumors is the
lack of truly tumor-specific target antigens, which translates to the targeting of tumor …

Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from
dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR) …

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with
infected or transformed target cells and then secreting cytotoxic perforin and granzyme into …

Neutrophil nuclear morphology has historically been used in haematology for neutrophil
identification and characterisation, but its exact role in neutrophil function has remained …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable
specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell …

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin
network to drive the polarized secretion of lytic granules, initiating target cell death during …

Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …

The centrosome acts as a microtubule-organizing center (MTOC) from the G1 to G2 phases
of the cell cycle; it can mature into a spindle pole during mitosis and/or transition into a cilium …